Tuesday, August 28, 2012

Foreign Policy: Who Has Romney's Ear?

To hear some advisers tell it, the Romney campaign is really Romney Inc., a smoothly-run organization that efficiently funnels the views of a vast array of foreign-policy advisers through a few key coordinators who brief the candidate. This is a positive contrast to the last time Mitt Romney ran in 2008. ?The last time, it was me, the governor, and five other people sitting around a table. We didn?t do that well,? says Mitchell Reiss, the former head of policy planning at the State Department who is one of a wide selection of advisers Romney brought on from the Bush administration. "Now it?s a $500 million operation ... and there so many more people who have expertise.?

But other advisers inside the campaign say this expertise is still not being well employed, which may be one reason Romney appeared so amateurish during his recent gaffe-strewn tour through Britain, Israel, and Poland. According to one Romney adviser who would discuss the internal dynamics of the campaign only on condition of anonymity, there is an ?experience gap? between the inner circle of people who talk to Romney directly and the many on the outside who have to funnel their views through that inner circle, especially through the young and untested foreign-policy coordinator, Alex Wong.

?A lot of people with experience in government are not in the inner circle,? says this adviser. Some of the former government officials who are nominally on Romney?s foreign-policy advisory teams say they haven?t briefed the candidate personally since 2011. Other advisers speak out or write op-eds on their own,?leading to the perception that there are publicly-aired disputes inside the campaign when in truth few of these advisers are actually in contact with Romney.

The lingering sense that Romney?s foreign-policy views remain somewhat inchoate could affect not only voters? calculations but also possibly those of the Israelis, who are believed to be contemplating whether to attack Iran?s nuclear facilities before the election. While Romney took a hard line in supporting Israel?s right to defend itself on his trip?and he is closer to Prime Minister Benjamin Netanyahu, who is said to favor a strike, than Obama is--he went out of his way to avoid endorsing an Israeli strike.

The disarray feeds Israeli worries about waiting. ?There is a belief that whether Obama or Romney wins, everything is more complicated? for the Israelis if they wait, says David Makovsky of the Washington Institute for Near East Peace. ?If Romney wins, he needs to get inaugurated, name staff, get them confirmed, and do policy reviews. That could take them till next fall,? which may well be beyond the Israeli window for action against Iran?s mountain nuclear site at Fordow, which is under construction.

Meanwhile, however, the Israelis?who are engaged in their own intense debate about whether to strike?hear a cacophony of voices in the Romney camp. ?We?ve got a very big tent. You?ve got a lot of different voices,? concedes another Romney adviser. ?The debate isn?t ?Gee, can we live with an Iranian nuclear weapon,? it?s how you structure a response.? Even so, with Romney playing to his conservative base, ?there hasn?t been a big conversation of how much would he put back into a diplomatic effort? with Iran, the first adviser says.

The Romney foreign-policy inner circle starts with Wong, who bears the expansive title of ?director of foreign, defense, and judicial policy? and who conducts the weekly conference call with advisers. Wong is a 2007 Harvard Law School graduate and a former associate at the law firm of Covington & Burling, but his credentials as a foreign-policy expert are thin at best, amounting to a summer internship at the U.S. mission to the U.N. in 2005. The circle also appears to include Dan Senor, the former spokesman for the Coalition Provisional Authority in Iraq who co-wrote a 2009 book on Israel?s entrepreneurial culture, Start-Up Nation, which was cited by Romney during much- criticized remarks he made at a Jewish fundraiser in July appearing to denigrate Palestinians. Senor, who like Romney is a sometime Wall Street financier with a Harvard Business School degree, accompanied Romney on the Mideast leg of his trip last month.

Reiss is also considered by some to be close to Romney, along with former ambassador Rich Williamson, although by Reiss?s own testimony he himself doesn?t talk to Romney much. He says Wong is the ?gatekeeper,? and the process works well. The internal complaints, Reiss adds, are just ?sour grapes. People aren?t getting face time. They?re not getting stroked the way they might want to get stroked, but the reality is it?s a much bigger operation. There?s no requirement for us to do this in person.?

Reiss adds that ?there are a number of us who have been with him for a while, that have ability to talk to directly when we feel? it?s necessary.... I think all of us refrain? from doing that unless there?s an emergency.? Wong, he adds, ?gives a very accurate and honest reflection of what it is we? re saying,? which often goes to Lanhee Chen, the head of policy, and then to Romney.

The Romney campaign is trying hard to stay on unified message. When National Journal contacted one Romney foreign policy adviser, Ashley Tellis, a former senior adviser to the State Department on India, he declined an interview, saying, ?I?m not supposed to discuss this with anyone. I?m under strict instructions not to.? Another adviser, Princeton scholar Aaron Friedberg, who was former Vice President Dick Cheney?s deputy for national security, simply passed along an e-mail to Andrea Saul, the Romney campaign?s spokesperson.

Saul did not respond to a separate e-mail requesting comment.

Source: http://news.yahoo.com/foreign-policy-romneys-ear-060006528.html

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NASA gets set for yearlong stays in orbit

NASA will shortly announce plans to double the mission duration of some astronaut expeditions to the International Space Station, NBC News has learned. Beginning as early as 2015, some of the astronauts and cosmonauts sent into orbit will remain there not the usual six months, but for a full year.

In Houston last week, NASA spokesman Kelly Humphries acknowledged that the project was under study but said it was still only a proposal. "All we can say is that we are exploring possibilities," he said in an Aug. 21 email. "There have been no formal decisions made, and it is premature to speculate what the outcome might be."

But sources familiar with NASA's plans say the preparations for such a mission are much more advanced than this description suggests. Specific mission dates and crew candidates are already being assessed. The sources discussed the plans on condition of anonymity because they were not yet due to be announced publicly.

  1. Space news from NBCNews.com

    1. Flags?will fly at half-staff for Neil Armstrong

      Science editor Alan Boyle's blog: President Barack Obama orders that U.S. flags be flown at half-staff in honor of first moonwalker Neil Armstrong, who passed away over the weekend.

    2. NASA gets set for yearlong stays in orbit
    3. Rover sends first human voice from Mars
    4. Will.i.am song will get Red Planet premiere

Speculation about the specifics as well as the general mission overview is entirely justified, due to its potential significance to the future of human space activity. That is because the extension of zero-G exposure will be aimed mainly at measuring the potential physiological impacts of spaceflights long enough to accomplish the human interplanetary missions envisaged beginning in the 2020s.

It is this new mission that will coincidentally open up the opportunity for the Russian space program to resume selling "space tourist" tickets into orbit, as reflected by the recent reports about a potential flight for British singer Sarah Brightman .

The Russians halted these space passenger missions three years ago as the International Space Station crew size increased from three to six and NASA space shuttle missions drew to a close. Due to the retirement of the shuttle fleet, every ticket on every three-seat Soyuz launch had to be used by a long-term station resident. There were no longer any spare tickets for visitors, even though there are now four Soyuz launches per year instead of the previous two per year.

Having some station residents "stay over" their normal rotation to Earth will again open a spare seat, perhaps two. The Russians are said to be enthusiastic about the idea, with tickets going at a price upwards of $35 million each.

Vitaly Lopota ? the president of Russia's Energia rocket company, which is in charge of building the Soyuz craft for Russia's Roskosmos space agency ? confirmed on Monday that there have been requests for space passenger seats. "If there is a team, we'll start work, but besides a team, funds are needed," Russia's Interfax-AVN news service quoted Lopota as saying. "We need the resources before the end of the year."

Lopota said the short-term tourist trips would be easier to organize if the 12-month mission plan was put into effect.

On the American side, the plan could have election-year significance. It could help the White House underscore the seriousness of its commitment to American leadership in human spaceflight beyond low Earth orbit, where the space station operates.

So far, NASA's strategy for exploration beyond Earth orbit has been mostly just talk and long-range planning for bigger rockets. Battles over booster designs and budgets, and even an unresolved issue as basic as selecting an actual destination in space for future astronauts, have contributed to the impression that little or nothing is happening.

That may change. Although NASA turned down the idea of staging 12-month orbital missions eight years ago , the enthusiasm over the recent success of NASA's Curiosity lander on Mars has now created a public atmosphere supportive of such bold projects, sources within NASA have told NBC News.

Base motives for idealistic missions
Justifying this major advance in human space exploration through appeals to cash flows and election-year politicking may seem a bit tawdry, but it?s really more the rule than the exception in history.

After all, the greatest exploratory expeditions of human history have often been motivated at least in part by the quest for wealth and power. Whether it was the Columbus voyages, or the ?Corps of Discovery? of Lewis and Clark, or Project Apollo, the primary motivating factor that led to getting the funds was "What?s in it for me?"

But whatever the base desire for short-term benefits ? many of which never actually materialized ? such activities have delivered profound and widespread gains in acquired knowledge and cultural inspiration. Usually, the results more than justified any short-term financing deals.

So it should come as no surprise ? and should be no cause for shame ? that as Russia and the United States together gather their energies to launch forth on long space endurance runs, the motives foremost in their governments? minds are all too mundane.

So what? These flights, first to 12 months and then conceivably to 18 or even 24 months or longer over the next decade, are the first practical steps on the ladder of capabilities rising toward human interplanetary flight. Together with life-support hardware already in advanced testing on the space station, such a program is critical for finally getting out of low Earth orbit.

Long-term precedents
Yearlong spaceflights have been made before, with no indication of significant medical issues. One Russian crew in 1987 spent 366 days in space, and in 1994-1995, Valery Polyakov spent a total of 14 months aboard Mir. But these were record-seeking one-offs with no follow-up.

What's more, space medicine specialists around the world have long questioned the quality of the Russian medical data from those flights. Cosmonauts later admitted faking a lot of the test results, for sport on boring missions. In the 1980s, even the Soviet space medicine establishment relied on heavily instrumented Skylab medical baselines, even though their own missions had flown twice as long, then even longer.

Even the current standard "duty tour" of six months in space is an operational accident with no rational medical basis. NASA doctors preferred about 4 months as the optimal mission duration, when station astronauts were transported on shuttle flights. Cosmonauts agreed. They reported growing fatigue in the final month or two of their half-year space sojourns.

A six-month tour is purely a result of the design lifetime of the Russian Soyuz ferry craft, with the limit flexible enough to push up to seven months in a pinch. After that, chemical decomposition of propellants in the landing capsule could potentially reach levels rendering the fuel unusable for guiding the craft's re-entry.

In addition, NASA doctors have developed another arbitrary stick-in-the-spokes for serious long-term missions. An arbitrary upper limit on cancer threat from radiation exposure essentially limits American astronauts to no more than about a year total spaceflight time.

An American astronaut who was yanked off a space station flight due to "excessive" radiation exposure from a ground medical procedure bitterly told NBC News: "It?s a sham standard." He explained: "It doesn?t reduce the cumulative health impact, since cancer threat is linear with duration. It only redistributes it."

The astronaut expressed the opinion that crew candidates be given the option of accepting or declining the hazard, balanced against their own individual medical histories and career plans. And to make these longer flights, his advice will need to be taken by NASA doctors, although it would be too late to be of any help to himself.

Commuting the Earth-space route
The actual scheduling of a 12-month mission onto the existing traffic pattern to and from Earth orbit is surprising complex. The pattern of the current crew transport to the space station is well-established, and there is little likelihood of any significant modification to it before the beginning of commercial crew transport in 2016 or so.

Four Soyuz spacecraft are launched every year, each carrying three crew members. The commander is always a Russian cosmonaut, and one crew member is always an American astronaut. The choice for the third crew member alternates between a Russian cosmonaut and an "international partner" such as a Japanese, Canadian or European astronaut.

With six people aboard the space station, crew rotation occurs when the three members of a returning crew get into their own Soyuz and head back to Earth. This leaves only three crew members on the station for several weeks. The staffing returns to six when a new crew is launched.

That full staffing reflects a careful plan worked out by the international partnership to allocate three seats to Russia and three to the "U.S. segment." NASA allocates one of those three seats to the astronaut from Japan, Canada or Europe.

What this means is that Russia has a second Soyuz seat ? the one they are allowed to "sell" ? only every other Soyuz launch. And when they do, the third seat is occupied by an American astronaut.

To send one Russian and one American on a 12-month mission requires careful planning. The crucial choice is dictated by the fact that the six-months-along mission, the one that would normally be used for the rotation of the original crew, must have had two Russian seats on it. One would be for the pilot, and one would be available for Russia to sell to a paying customer. That means that the third seat would, by rights, be occupied by an American astronaut.

This ?stayover? mission cannot wait for the previous six-month Soyuz to land ? since two of the previous Soyuz's crew members intend to remain in orbit. So the Soyuz must launch while the earlier two Soyuzes are both still docked to the station.

There are four docking ports for Russian spacecraft, so mechanically this isn?t too difficult. It was already done once, in 2009, for the first crew rotation after the station permanent crew size went from three to six. But there are tricky issues with three docked Soyuzes, including safe emergency evacuation procedures for all three spacecraft. These issues need to be thoroughly worked out.

Who gets the short straw?
An even trickier issue has to do with the fact that the Russian pilot of the "stayover" Soyuz will be replacing the Russian pilot of the Soyuz-before-last, so that the pilot on the station can return after six months. But the two crew members who accompanied that pilot into space six months earlier will be staying aboard, headed for their full-year tour. So, two of the crew members of the "stayover Soyuz" will switch over and accompany the departing pilot on the earthbound Soyuz.

Now here?s the tricky part. One of those two short-term fliers, in what normally would be the "Russian seat," can be the cash customer. But the other would have to be an American astronaut. That astronaut would be forced to return to Earth after only a short mission, perhaps spending less than two weeks in orbit.

Why should NASA have to pay full launch price ? around $65 million ? for a mission that will last only a tenth as long as the standard duty tour?

If the Russians let NASA out of its contracted plan to use the seat and offer it to a commercial space passenger, the revenue from that seat would be around $35 million ? half of the rate that NASA would be charged. That would represent a financial loss for Russia that could be as nearly great as the entire profit from the first ticket sale.

It would end up being a wash. It would mean selling one seat to NASA for $65 million, or two seats to two commercial space travelers for around $35 million each. From the Russian point of vew, the American side must pay full price for its truncated space stay, or Russia makes virtually no money at all for the entire deal.

There is a variety of alternative seating schemes, as well as the possibility of staggering the Russian and American long-termers on successive launches. NBC News has learned that the "staggering" option is being seriously considered. It will be interesting to observe how both sides dance around these practical matters in designing the actual mission.

Whatever the arrangements turn out to be, the rationalizations and compromises will soon be forgotten as part of the nitty-gritty, real-world wheeling and dealing to extract maximum national benefits from the opportunity. What won?t be forgotten is the result: the first major sustained advance in human spaceflight endurance in two decades, an advance that will finally dispel enough dragons and "unknown unknowns" to open the door to deep-space journeys.

Best of all, the opening will have been achieved methodically and prudently, without reliance on the gung-ho adventurism and deliriously wishful thinking of "Mars mission" crusaders of the past. The odds of avoiding disaster are so much better this way.

More about long-duration spaceflight:

NBC News space analyst James Oberg spent 22 years at NASA's Johnson Space Center as a Mission Control operator and an orbital designer. He is the author of several books on space history and space policy, including "Star-Crossed Orbits: Inside the U.S.-Russian Space Alliance."

Source: http://www.msnbc.msn.com/id/48807002/ns/technology_and_science-space/

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Targeted oxidation-blocker prevents secondary damage after traumatic brain injury

Targeted oxidation-blocker prevents secondary damage after traumatic brain injury

Monday, August 27, 2012

Treatment with an agent that blocks the oxidation of an important component of the mitochondrial membrane prevented the secondary damage of severe traumatic brain injury and preserved function that would otherwise have been impaired, according to a research team from the University of Pittsburgh School of Medicine, Graduate School of Public Health and Department of Chemistry in a report published online today in Nature Neuroscience.

Annually, an estimated 1.7 million Americans sustain a traumatic brain injury (TBI) due to traffic accidents, falls, assaults and sports participation, said the study's senior author H?lya Bay?r, M.D., associate professor, Department of Critical Care Medicine, University of Pittsburgh School of Medicine. She added that 52,000 of those injured die, and 85,000 are left with significant disability.

"We don't yet have a specific therapy for TBI, but can provide only supportive care to try to ease symptoms," Dr. Bay?r said. "Our study drug shows promise as a neuroprotective agent that might help address this important public health problem."

For the study, the research team conducted a global assessment of all the phospholipids in rat brain cells. This revealed that damage from TBI was nonrandom and mostly involved cardiolipin, a phospholipid that is found in the membranes that form mitochondria, the cell's powerhouse. They noted that in the healthy animal, only 10 of the 190 cardiolipin species were modified by oxygen, but after a brain injury, the number of oxidized species rose many-fold.

The researchers then developed an agent, called XJB-5-131, which can cross the blood-brain barrier and prevent the oxidation of cardiolipin. Using an established research model of severe TBI, the agent or a placebo was injected into the bloodstream of rats five minutes and again 24 hours after head injury.

In the weeks that followed, treated animals performed akin to normal on tests of balance, agility and motor coordination, learning, and object recognition, while placebo-treated animals showed significant impairment. The results indicate that blocking cardiolipin oxidation by XJB-5-131 protected the brain from cell death.

"The primary head injury might not be that serious," Dr. Bay?r noted. "But that initial injury can set into motion secondary cellular and molecular events that cause more damage to the brain and that ultimately determine the outcome for the patient."

She added that a targeted oxidation-blocker might also be beneficial in the treatment of other neurological disorders, such as Parkinson's disease, amyotrophic lateral sclerosis, or ALS, and stroke.

###

University of Pittsburgh Schools of the Health Sciences: http://www.upmc.com/Pages/default.aspx

Thanks to University of Pittsburgh Schools of the Health Sciences for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

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Source: http://www.labspaces.net/122943/Targeted_oxidation_blocker_prevents_secondary_damage_after_traumatic_brain_injury

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Monday, August 27, 2012

The War of Mortals and Immortals.

The War of Mortals and Immortals.

Supernatural beings seek the guidance of Vlad the Impaler in a war against all of humanity.

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Sharp day for Peyton

Randy Bullock, Shayne GrahamAP

The Texans? kicking competition is over, as fifth-round pick Randy Bullock will be placed on injured reserve with a torn groin muscle.

That means journeyman Shayne Graham will win the job by default, although he had kicked well in the preseason.

Bullock injured the muscle earlier in camp, and missed some practice time. Texans coach Gary Kubiak said it was the reason he didn?t have the length on kickoffs they expected when they drafted Bullock out of Texas A&M.

?He came in today, and [the groin area] was black and blue,? Kubiak said, via John McClain of the Houston Chronicle. ?He couldn?t even lift a leg. I?m really disappointed for the kid because he had kicked very well. But I?m also happy for Shayne because he?s done a great job.?

The 34-year-old Graham is in his 13th season. He made a Pro Bowl with the Bengals, and has also spent time with the Saints, Seahawks, Bills, Panthers, Ravens, Giants, Patriots, Redskins, Cowboys and Dolphins.

He was 5-of-5 on field goals, including from 48, 49 and 53, with good distance on kickoffs.

And judging by the sideburns in that picture, he?s gotten tired of being compared to Opie Taylor as he?s gotten older.

Source: http://profootballtalk.nbcsports.com/2012/08/26/peyton-manning-done-after-three-drives/related/

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Sunday, August 26, 2012

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Vijayawada Bangalore: Travel By Volvo

Vijayawada Bangalore is 650 km apart and it takes around ten hours to cover this distance by road. However, since the roads are so good at this stretch that you dont feel even for a second that you are travelling ten hours in the bus. Moreover, the buses these days are also very comfortable with enough room for legs. There is LCD in the bus to offer you with latest movies back to back throughout the journey. The luggage is kept in a separate cabin altogether and you need not worry about it till the time you reach your destination.

All such services are offered by no other bus but Volvo. There are many Volvo buses operating on Vijayawada Bangalore stretch. they are fast and take much less time in comparison to any other bus on this route. The best part about these Volvo buses is that they are available after every hour. No matter what time of the day your want to travel from Vijayawada Bangalore, you can easily do.

However, the best time to cover these ten hours is normally considered at night when the traffic is also not very heavy and you can sleep off the night. There are many Vijayawada Bangalore Volvo buses that start from 7pm at night and the last bus can be boarded at 11:30 at night. These buses normally stop only for dinner and later early in the morning for tea. Thus, without wasting any time, they make you reach your destination in ten hours.

In order to book Vijayawada Bangalore Volvo bus, you can log on to internet. Many private operators offer online tickets. You can also book for KSRTC Volvos online. No matter whether you book for private or a State Government Volvo bus service, you can enjoy online booking facilities.

Similar to Vijayawada Bangalore Volvos, there are many buses from Hyderabad to Nagpur also. It takes five hours only to cover this distance and you dont even come to know about the journey in a Volvo. Other than Volvo, there are many cheap buses from Hyderabad to Nagpur that charge almost half the fare of a Volvo bus. However, it is a different experience to travel in a Volvo.

If you are not too tight on budget, it is recommended to give Volvo bus a try. It will make your journey good fun. You would not be worried about your luggage also.

About the Author:
Online booking of Bus Tickets from Vijayawada to Bangalore with MakeMyTrip.com. Online Bus reservation and list of all the buses running from Vijayawada to Bangalore with bus schedule and timetable.

Source: http://www.articlesnatch.com/Article/Vijayawada-Bangalore--Travel-By-Volvo/4120647

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