Thursday, April 11, 2013

Video: Shedding light on a gene mutation that causes signs of premature aging

Tuesday, April 9, 2013

Research from Western University and Lawson Health Research Institute sheds new light on a gene called ATRX and its function in the brain and pituitary. Children born with ATRX syndrome have cognitive defects and developmental abnormalities. ATRX mutations have also been linked to brain tumors. Dr. Nathalie B?rub?, PhD, and her colleagues found mice developed without the ATRX gene had problems in in the forebrain, the part of the brain associated with learning and memory, and in the anterior pituitary which has a direct effect on body growth and metabolism. The mice, unexpectedly, also displayed shortened lifespan, cataracts, heart enlargement, reduced bone density, hypoglycemia; in short, many of the symptoms associated with aging. The research is published in the Journal of Clinical Investigation.

Ashley Watson, a PhD candidate working in the B?rub? lab and the first author on the paper, discovered the loss of ATRX caused DNA damage especially at the ends of chromosomes which are called telomeres. She investigated further and discovered the damage is due to problems during DNA replication, which is required before the onset of cell division. Basically, the ATRX protein was needed to help replicate the telomere.

Working with Frank Beier of the Department of Physiology and Pharmacology at Western's Schulich School of Medicine & Dentistry, the researchers made another discovery. "Mice that developed without ATRX were small at birth and failed to thrive, and when we looked at the skeleton of these mice, we found very low bone mineralization. This is another feature found in mouse models of premature aging," says B?rub?, an associate professor in the Departments of Biochemistry and Paediatrics at Schulich Medicine & Dentistry, and a scientist in the Molecular Genetics Program at the Children's Health Research Institute within Lawson. "We found the loss of ATRX increases DNA damage locally in the forebrain and anterior pituitary, resulting in systemic defects similar to those seen in aging."

The researchers say the lack of ATRX in the anterior pituitary caused problems with the thyroid, resulting in low levels of a hormone called insulin-like growth factor-one (IGF-1) in the blood. There are theories that low IGF-1 can deplete stores of stem cells in the body, and B?rub? says that's one of the explanations for the premature aging. This research was funded by the Canadian Institutes of Health Research.

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University of Western Ontario: http://www.uwo.ca

Thanks to University of Western Ontario for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

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Source: http://www.labspaces.net/127648/Video__Shedding_light_on_a_gene_mutation_that_causes_signs_of_premature_aging

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Tint Gives Businesses An Easy Way To Bring Social Media Feeds To Their Websites, Apps And Facebook Pages

Screen shot 2013-04-10 at 9.02.17 PMLast year, Tim Sae Koo, Nikhil Aitharaju, Eunice Noh and Ryo Chiba launched HypeMarks to give people a less hectic way to consume social media. The startup aggregated tweets, articles, links and more shared by influencers and celebrities on social media accounts and, by grouping those by topic, aimed to give people a snapshot of an industry through the eyes of the people who know it best.

Source: http://feedproxy.google.com/~r/Techcrunch/~3/05E_zSIrbKU/

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Wednesday, April 10, 2013

Matt Damon's 'Elysium' Trailer: Watch Now!

Damon goes head-to-head with Jodie Foster in sneak peek of Neill Blomkamp's 'District 9' follow-up.
By Todd Gilchrist


Matt Damon in "Elysium"
Photo: Sony Pictures

Source: http://www.mtv.com/news/articles/1705293/elysium-trailer.jhtml

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New Couple Alert? Charlize Theron & Seth MacFarlane

New Couple Alert? Charlize Theron & Seth MacFarlane

Charlize Theron dating Seth Macfarlane?Charlize Theron and Seth MacFarlane were spotted out on a dinner date in West Hollywood last night! Charlize and Seth met up for sushi at Matsuhisa Restaurant in Beverly Hills and were spotted leaving together. Charlize Theron is back in Los Angeles after working as the executive producer on the upcoming series “Hatfields & McCoys” ...

New Couple Alert? Charlize Theron & Seth MacFarlane Stupid Celebrities Gossip Stupid Celebrities Gossip News

Source: http://stupidcelebrities.net/2013/04/new-couple-alert-charlize-theron-seth-macfarlane/

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Navy to unveil new laser weapon

No longer the fantasy weapon of tomorrow, the U.S. Navy is set to field a powerful laser that can protect its ships by blasting targets with high-intensity light beams.

Early next year the Navy will place a laser weapon aboard a ship in the Persian Gulf where it could be used to fend off approaching unmanned aerial vehicles or speedboats.

The Navy calls its futuristic weapon LAWS, which stands for the Laser Weapon System. What looks like a small telescope is actually a weapon that can track a moving target and fire a steady laser beam strong enough to burn a hole through steel.

A Navy video of testing conducted last summer off the coast of California shows how a laser beam fired from a Navy destroyer was able to set aflame an approaching UAV or drone, sending it crashing into the ocean.

"There was not a single miss" during the testing, said Rear Admiral Matthew Klunder, chief of Naval Research. The laser was three for three in bringing down an approaching unmanned aerial vehicle and 12 for 12 when previous tests are factored in.

But don't expect in that video to see the firing of colored laser bursts that Hollywood has used for its futuristic laser guns. The Navy's laser ray is not visible to the naked eye because it is in the infrared spectrum.

Many of the details about how the laser works remain secret, such as how far its beam can travel, how powerful it is or how much power is used to generate it.

But Navy officials have provided a few unclassified details. For example, the laser is designed to be a "plug and play" system that integrates into a ship's existing targeting technologies and power grids. Those factors make it a surprisingly cheap weapon.

Klunder says each pulse of energy from the laser "costs under a dollar" and it can be used against weapons systems that are significantly more expensive. The Navy says it has spent about $40 million over the past six years in developing the weapon.

Rear Admiral Thomas Eccles, Navy Sea Systems Command, says the beam can be turned on instantly and that ultimately "the generation of power is essentially your magazine. It's the clip we have" instead of bullets. "We deliver precision with essentially an endless supply of rounds."

Some new technological fixes, what Klunder calls "a secret sauce," have been developed to improve the degrading of lasers over distance as well as maintaining a lock on a target from a moving ship.

The strength of the beam is flexible enough that at a lower intensity level it can be used to warn approaching ships and UAV's not to get too close to a Navy ship. Instead of using machine guns to fire non-lethal warning shots as Navy ships do now, the laser can be aimed to "dazzle" the viewing sensors aboard the craft. That light effect warns the pilot of a small water craft or at the controls of a UAV that they are being targeted by a laser and to turn away. If they don't, the laser's power can be boosted to destroy the approaching craft.

Based on earlier testing the Navy is confident the laser is ready for real-world testing aboard the USS Ponce in the Persian Gulf. The ship was selected because of its mission to be an enduring presence in the Gulf to counter Iranian maritime threats in the region. Coincidentally Iran uses small fast boats to harass American warships in the waters of the Persian Gulf.

How might Iran feel about the new weapon? "Frankly I hope it sends a message to some of our potentially threatening adversaries out there to know that we mean business," said Klunder. "This is a system where if you try to harm our vessels that I hope you will take a very, very serious moment of pause to think about that before you do it because this system will destroy your vessel or will destroy your UAV."

The Navy wants the ship's crew to use the same techniques and methods they use with their other defensive weapons systems.

While for now the laser will be used primarily against slow-moving UAV's and fast boats cruising at speeds of 50 knots, the Navy sees the system's capabilities expanding over time to target faster weapons.

"There's absolutely every intention that with the development of this system and follow-on upgraded systems we will eventually be able to take higher speeds in-bound," said Klunder.

Also Read

Source: http://news.yahoo.com/navys-laser-weapon-blasts-bad-215808231.html

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App Stores In Q1 2013 Hauled In $2.2B In Sales On 13.4B Downloads, Google/Apple Duopoly Leading The Way: Canalys

Image1 for post Just How Much Money Can Free iPhone Apps Make?  Quite A BitApple's App Store and Goole Play on Android continue to set the pace for the overall performance and fortunes of mobile apps worldwide, while BlackBerry and Microsoft's Windows Phone remain "distant challengers." Figures out today from Canalys note that in Q1 2013, the four top app stores worldwide collectively accounted for 13.4 billion downloads, with $2.2 billion in paid app sales, in-app purchases and subscriptions. But while Google has long passed Apple as the biggest smartphone platform worldwide, Apple is still killing it when it comes to monetizing: Google Play accounted for 51% of all downloads (6.8 billion), but Apple's App Store for 74% of all revenues ($1.6 billion).

Source: http://feedproxy.google.com/~r/Techcrunch/~3/hbB9f_EuqLs/

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Tuesday, April 9, 2013

Cabela's to Hire 200 to Staff New Green Bay, Wis., Store

Applications being accepted now, according to general manager Steve Farone.

Cabela?s Green Bay, Wisconsin Store

Cabela?s Green Bay, Wisconsin Store

Cabelas

Cabelas

SIDNEY, Neb. --(Ammoland.com)- Cabela?s Incorporated, the World?s Foremost Outfitter of hunting, fishing and outdoor gear, plans to hire approximately 200 full-time, part-time and seasonal employees to staff its new Green Bay, Wis., store scheduled to open this summer.

Applications are being accepted now and interviews will begin April 22, continuing through April 26.

To apply, visit www.cabelas.jobs, click on ?Apply Now,? then ?United States Jobs,? and select ?Green Bay.? Follow instructions to log in. Applications must be submitted online. Applying does not guarantee an interview.?http://tiny.cc/jdp8uw

Most employees are expected to come from Green Bay and the surrounding area. Typically, Cabela?s attracts applicants with detailed knowledge about the outdoors and an aptitude for customer service.

?Cabela?s is looking for employees who will deliver legendary customer service, and who will be excited about sharing their passion and knowledge of the outdoors with our many loyal customers across the area,? said Steve Farone, general manager of the new store.

The 100,000-square-foot store is located at 1499 Lombardi Ave N near Lambeau Field in the Village of Ashwaubenon in Brown County. It is Cabela?s third Wisconsin store, joining the Richfield and Prairie du Chien locations. In addition to thousands of quality outdoor products, the store will feature a mountain replica, aquarium, indoor archery range, dynamic wildlife displays, Gun Library, Bargain Cave, Deli, Fudge Shop and Sportsman?s Hall of Fame displaying Wisconsin trophy animal mounts.

Currently, Cabela?s operates 43 stores across the United States and Canada. The company has announced plans to open an additional 12 stores by the end of 2014.

www.cabelas.com

About Cabela?s Incorporated
Cabela?s Incorporated, headquartered in Sidney, Nebraska, is a leading specialty retailer, and the world?s largest direct marketer, of hunting, fishing, camping and related outdoor merchandise. Since the Company?s founding in 1961, Cabela?s? has grown to become one of the most well-known outdoor recreation brands in the world, and has long been recognized as the World?s Foremost Outfitter?. Through Cabela?s growing number of retail stores and its well-established direct business, it offers a wide and distinctive selection of high-quality outdoor products at competitive prices while providing superior customer service. Cabela?s also issues the Cabela?s CLUB? Visa credit card, which serves as its primary customer loyalty rewards program. Cabela?s stock is traded on the New York Stock Exchange under the symbol ?CAB?.

Source: http://www.ammoland.com/2013/04/cabelas-to-hire-200-to-staff-new-green-bay-wis-store/

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