Saturday, February 2, 2013

Wall Street rallies on upbeat data

NEW YORK (Reuters) - Stocks hit five-year highs on Friday after jobs and manufacturing data showed the economy's sluggish recovery is still on track.

The Dow industrials hit 14,000 for the first time since mid October 2007 and the S&P hit its highest level since December that year. The S&P gained 5 percent last month, its best start to a year since 1997.

Employment grew modestly in January, with 157,000 jobs added in the month, slightly below expectations for 160,000. Still, figures for both November and December were revised upwards.

Separate reports showed the pace of growth in the U.S. manufacturing sector picked up in January to its highest level in nine months, U.S. consumer sentiment rose more than expected last month, and December construction spending came in higher than forecasts.

"All the data seems to keep pointing to a slowly, steadily improving economy," said Eric Kuby, chief investment officer at North Star Investment Management Corp in Chicago.

Market sentiment is pointing to weaker bond prices as stocks are moving up, and the economy seems to be confirming that trend, he said.

The Dow Jones industrial average <.dji> rose 138.31 points or 1 percent, to 13,998.89, the S&P 500 <.spx> gained 12.26 points or 0.82 percent, to 1,510.37 and the Nasdaq Composite <.ixic> added 22.82 points or 0.73 percent, to 3,164.95.

With the day's gains, major averages were on track for a fifth straight week of gains. The S&P 500 is also coming off its best monthly performance since October 2011.

Corporate earnings were also in focus, with a trio of Dow components reporting profits that beat expectations.

Exxon Mobil was little changed at $89.88 after its results while Chevron added 0.7 percent to $115.97.

Drugmaker Merck & Co fell 2.9 percent to $42 after a cautious 2013 outlook.

Generic drugmaker Perrigo reported a better-than-expected second-quarter profit and its shares were up 6.2 percent at 106.75, the largest advancer on the S&P 500.

Of the 252 companies in the S&P 500 reporting earnings so far, 69 percent have exceeded expectations, according to Thomson Reuters data. That is a higher proportion than over the past four quarters and above average since 1994.

Overall, S&P 500 fourth-quarter earnings are estimated to rise 4.4 percent according to the data, up from a 1.9 percent forecast at the start of the earnings season but well below a 9.9 percent profit growth forecast on October 1.

Dell Inc gained 4.8 percent to $13.86 after sources said the company was nearing an agreement to sell itself to a buyout consortium led by its founder Michael Dell and private equity firm Silver Lake Partners.

Shares of Zoetis surged in their trading debut after the company's initial public offering was priced at $26, above the expected range. After spiking as high as $31.74, it pared its gains to trade at $30.74.

(Reporting by Rodrigo Campos; Editing by Nick Zieminski)

Source: http://news.yahoo.com/p-500-posts-biggest-monthly-gain-since-october-001324077--sector.html

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Sony Xperia Z priced at ?529, less if you buy it from Three (update: free headphones with preorders)

Sony Xperia Z gets priced at 52900, less if you buy it from Three

The humble islanders who inhabit Great Britain are waking up to the news that Sony's Xperia Z has been priced in the local currency. They can pre-register the unit for £529 in a choice of black, white or purple hues direct from Sony, or pre-order for £449 on Three. Either way, early birds stand to get a free pair of MDR-1R cans with their handset -- worth £200 ($315) no less.

Update: Vodafone has tweeted that the phone will launch (at least in the UK) on February 28th -- a few days earlier than we'd heard before.

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Via: GSMArena

Source: Sony UK, Three

Source: http://www.engadget.com/2013/02/01/xperia-z-uk-pricing/

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Friday, February 1, 2013

Warm Bodies

Nicholas Hoult as R. in Warm Bodies Nicholas Hoult as R. in Warm Bodies

Photo by Jonathan Wenk ? 2012 Summit Entertainment, LLC.

There?s a built-in obstacle to the high concept of Warm Bodies, from writer/director Jonathan Levine, whose zombie rom-com riffs on the Twilight formula of pairing a mortal girl with an undead boy: Not many people fantasize about getting it on with a zombie. Vampires?at least movie vampires, who have long existed at a considerable remove from Bram Stoker?s original, foul-breathed Count Dracula?are brooding, suave, marble-skinned, and sexy, possessed of superhuman physical gifts of strength and speed. Zombies are shuffling, mindless, visibly decaying ambulatory corpses who (with rare exceptions, as in the 28 Days movies) can be outrun by all but the lowest-paid movie extras. In the Twilight series, Edward was a teenager preserved eternally at the height of his youthful beauty. R. (Nicholas Hoult), the undead hero of Warm Bodies, looks more like a pouty-lipped teen idol whose body has been moldering for six months in a dumpster.

The fact of zombies? relative unsexiness needn?t necessarily preclude the possibility of a zom-rom-com, but Levine?s likable-enough fourth feature (his first three were All the Boys Love Mandy Lane, The Wackness, and 50/50) never quite rises to the challenge. I did enjoy Warm Bodies? premise, as explained in a quite funny opening voice-over that riffs on the loneliness of the single boy in the unfeeling crowd. R., a particularly soulful and introspective young zombie, introduces the post-apocalyptic landscape he calls home as he reflects that, when you spend most of your days staggering through an abandoned airport past crowds of fellow lurching brain-eaters, it?s tough to really connect. The closest thing he has to a friend is M. (Rob Corddry), who occasionally sits with R. at a dust-covered airport bar and grunts sympathetically.

The zombie community inhabits a shadow world whose laws and customs are never quite clear?a fuzziness that becomes a real problem in the movie?s plot-driven third act. After a global apocalypse whose origin, like his full name, R. can no longer remember, the world has been divided into the undead and the living, who build fortified walls to protect themselves from the marauding brain-eaters on the other side. General Grigio (an off-his-game John Malkovich), who seems?again vaguely?to be the commander of an anti-zombie militia, sends a group of young fighters, including his daughter Julie (Teresa Palmer), on a mission across the wall. Nearly all the humans are killed in a zombie raid, but fair Julie gets rescued by R., who?s fallen in love at first sight. He takes her to his hideout on an abandoned airplane?a hovel full of vinyl records and other treasures R. has scavenged from the once beautiful world around him.

This middle section, which should have been the movie?s most charming, never quite takes off into the romantic stratosphere. Maybe that?s because R.?s refusal to take Julie back to the world of the living upon her request smacks uncomfortably of abduction?though he insists he?s only trying to keep her safe from the brain-eaters, there are hints that he?s exaggerating the risk in order to keep her there longer. Or maybe it?s just that the ramping up of their romance is too uneven?in one scene Julie is shrinking in repulsion from the monster who?s holding her hostage; in the next she?s taking him for a giggly joyride in a long-undriven sportscar.

Nicholas Hoult?s shambling, insecure hero has an appealingly guileless sweetness, but it?s hard to do a lot with a character whose history and motives are this vague. (Why does R., alone among zombies, have this capacity for self-reflection?) It doesn?t help that R. speaks mainly in grunts for the first half of the film, though his voice-over? ?Don?t be creepy, don?t be creepy,? he instructs himself as he nervously approaches his beloved?provides some welcome psychological context, as well as the majority of the movie?s laughs.

The preternaturally pretty Palmer brings an unusual amount of spunk to her damsel-in-distress role?she has a game, jock-ish quality that makes her believable as a warrior and could have seen her through better action scenes than this movie provides. Levine seems more at ease with the scenes involving romance and friendship (including a touching dramatic moment with an unusually subdued Corddry) than during the choppy, rushed late sequences in which zombies and humans alike are set upon by a digitally animated army of ?bonies?: extra-dessicated, fast-moving superzombies who are never entirely convincing either as a plot contrivance, a threat, or a special effect.

Warm Bodies, which is based on a novel by Isaac Marion, explicitly presents itself as a Romeo and Juliet story, from the names of its central couple to a classic wherefore-art-thou balcony scene. But though it?s about a pair of lovers whose passion is strong enough to break down the barriers between life and death, this mildly amusing, sort-of-sweet comedy is strangely sexless and passion-free?these bodies, whether human or zombie, feel room-temperature at best.

Source: http://feeds.slate.com/click.phdo?i=5c6b209988fbb8277397b0fb0f7bfd8f

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5 great onscreen football moments

By Courtney Hazlett, NBC News

Football might have its biggest day of the year on Super Bowl Sunday, but thanks to the magic of movie- and television-making, the sport lives on in mythic proportions all year long. Here's a look at some of football's best onscreen moments:

"Clear eyes, full hearts, can't lose," was a phrase that generated?headlines during the 2012 presidential election, but it was actually made famous on the TV series "Friday Night Lights." The phrase was part of one of Coach Taylor's (Kyle Chandler) pep talks. Below, a mash-up of some of Coach's greatest phrases from the show.

Speaking of pep talks, Al Pacino's inspirational speech in "Any Given Sunday" could be to blame for the discomfort found in listening to "real" coaches give their halftime talks. Pacino is passionate, convincing and motivating. If at the end you aren't ready to "fight for every inch," well, maybe inspirational speeches just aren't for you. (Beware, there's some locker-room language in this one).

Less intense and far more amusing is the football scene in "The Wedding Crashers." The highlight is Bradley Cooper (who really became a household name thanks to the film) as Sack Lodge, a slightly creepy, overly competitive boyfriend who puts all his creepy, overly competitive qualities on display in what should be a friendly game of backyard touch football.

Turn back the clock for another backyard football game gone wrong. All Marcia Brady wanted to do on TV classic "The Brady Bunch" was tell the boys dinner was ready, and think about her dreamy date set for Saturday night. But ... OH, MY NOSE!

And since it's Super Bowl weekend, a weekend that's as much about football as it is the economic boost that comes from the big game, it seems fitting to end by saying, "Show me the money!"?

Do you have some great football scenes from film and television that you especially love? Take the discussion on over to Facebook and share them with us.

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Source: http://entertainment.nbcnews.com/_news/2013/02/01/16792126-ready-for-some-football-start-with-5-great-onscreen-moments?lite

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Pentax Optio WG-3 and WG-10 offer ruggedized shooting with a unique design, we go hands-on (video)

Pentax Optio WG3 and WG10 offer ruggedized shooting with a unique design, we go handson video

Some might call it ugly; we'll say unique. Regardless of your take on Pentax's ruggedized Optio housing, you'll get a capable waterproof shooter, with a handful of practical features. Two new models appeared this week at CP+ in Yokohama, Japan, and while both may look like they came from the same mold, the feature sets differ vastly. The more powerful compact, the WG-3, is also the slightly larger flavor. It packs a 16-megapixel CMOS sensor, a sharp 3-inch LCD and a 4x, f/2-4.9 lens. Its survivability stats, printed around the lens, include waterproof to 14 meters (46 feet), shockproof to 2-meter (6.5-foot) drops, crush-proof to 100 kilograms (220 pounds) of force and cold-proof to -10 degrees Celsius (14 degrees Fahrenheit). Then there's the WG-10, which is basically just a rebranded WG-1, so we won't focus much on that.

Both cameras have similar designs that scream "rugged" -- in other words, if you're a fan of Panasonic's original Toughbook design, you might find these attractive. They're incredibly solid-feeling, so while trade show tethers prevented us from doing any durability testing, they definitely look the part. We spent a few minutes with the WG-3 (or WG-III as indicated to the right of the lens) -- it's almost intimidating in appearance, as if it's telling other cameras to watch their backs. The display is sharp and bright and the camera was generally responsive, though it certainly won't break any records for speed. Interestingly, the WG-10, which we were originally told was a Target-exclusive, and therefore only available in red, was displayed with a black finish as well -- perhaps Pentax has different plans for that model in Japan, which makes sense, considering that there aren't any Target stores here. Either way, you should expect to see both of these hit stores in April, or you can sneak a peek now in our hands-on video after the break.

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Source: http://www.engadget.com/2013/01/31/pentax-wg-3-wg-10-hands-on/

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A new mechanism that contributes to the evolution of cancer

Friday, February 1, 2013

Cancer arises from the accumulation of mutations and structural changes in chromosomes, which in some cases give rise to combinations that favour the growth or expansion of the disease. In this context, chromosomes tend to lose or duplicate entire regions, although, the mechanisms that initiate these chromosomal abnormalities are not fully understood.

A study published this week in the journal Cell, in which researchers from the Spanish National Cancer Research Centre (CNIO) participated, demonstrates a new mechanism that explains how these changes originate in the chromosomes of tumour cells.

The work, led by Andre? Nussenzweig's group at the National Cancer Institute (NCI, USA), with the participation of CNIO researcher O?scar Ferna?ndez?Capetillo, shows that collisions between the machinery responsible for duplicating the DNA and for transferring this genomic information to the RNA for protein synthesis?a phenomenon known as transcription?are the cause of a very high proportion of the chromosomal alterations found in tumours.

Until now, it was believed that the majority of these problems originated in areas of the genome that were difficult to duplicate and which, therefore, required the completion of the entire S phase of the cell cycle; a stage in which cells duplicate their DNA. Due to this episode, these regions were especially exposed to breaks or aberrations.

The current study reveals that other areas of the genome also exist?those that replicate quickly early in S phase?that are prone to breakages. In particular, the researchers demonstrate that this occurs when these DNA regions that replicate, have surrounding genes that are being actively copied to RNA.

"In these cases, the collision between the two machineries, the duplication machine and the transcription machine, can be responsible for generating chromosomal alterations that are deadly for cells," says Ferna?ndez?Capetillo.

This study moves us a step closer to understanding the mechanisms that explain the chromosomal alterations in tumour cells most common in tumours. "This new mechanism can even explain up to 50% of the abnormalities associated with some types of leukaemia," says Ferna?ndez?Capetillo.

Furthermore, this work defines a new class of genomic fragile sites that might contribute to our understanding of the changes that took place in the genome throughout evolution.

###

Identification of Early Replicating Fragile Sites that Contribute to Genome Instability. Cell (2013). doi: 10.1016/j.cell.2013.01.006

Centro Nacional de Investigaciones Oncologicas (CNIO): http://www.cnio.es

Thanks to Centro Nacional de Investigaciones Oncologicas (CNIO) for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

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Source: http://www.labspaces.net/126574/A_new_mechanism_that_contributes_to_the_evolution_of_cancer

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House of Cards

Kevin Spacey and Robin Wright in House of Cards.

Kevin Spacey and Robin Wright in House of Cards

Photo by Melinda Sue Gordon/Knight Takes King Prod

Who was it that said, ?If you want a friend in Washington, get a dog?? Many attribute the quip to Harry Truman; others contend it was Olivia Pope. The maxim came to mind while watching the addictive Netflix original series House of Cards, 13 episodes of which will be available for bingeing on Friday. The show is dryly witty in its depiction of constancy and fidelity on the Potomac. And in the first scene, the protagonist, played by Kevin Spacey, kills a dog in cold blood.

To be clear, it?s a mercy killing: On the last day of 2012, while slithering into his tuxedo and preparing to take his wife (Robin Wright) out to ring in another year of elbow-rubbing, back-scratching, and palm-greasing, Congressman Frank Underwood hears an automotive commotion and a plaintive canine wail. A hit-and-run driver has left a neighbor?s dog whimpering in the street. Breaking the fourth wall to deliver a monologue about his philosophy of pain, Underwood puts the dog out of its misery with his bare hands. The scene (directed by David Fincher, who helmed this and several later episodes) constitutes a great bit of characterization: Spacey?s avid eyes imply that Underwood relishes doing unpleasant things. His relaxed movements suggest that he?s killed dogs before, at least metaphorically. His subsequent half-smirk seems to acknowledge a silver lining: That was unpleasant, but at least he got in some practice killing with his bare hands.

At the New Year?s Eve party, Underwood explains?directly to the camera again, in a terrifically effective device that lets him serve sometimes as his own Greek chorus, sometimes as a color commentator on blood sport?that he is the majority whip: ?My job is to clean the pipes and keep the sludge moving, but I won?t have to be a plumber much longer.? The president-elect had promised to nominate him for secretary of state, but Underwood very soon learns he?s been passed over, and hell hath no fury like a power-player passed over for a top-level Cabinet position. ?They?ve done us a great favor,? he tells a staff member, referring to his betrayers. ?We are no longer bound by allegiances.? Underwood?s interest in foreign affairs may be keen, but his passion for vengeance is total. His motto seems to be: When life gives you lemons, spike them with arsenic and put into effect an intricate plan to get the kids who live across the street from your worst enemy to build a lemonade stand. The top items on Underwood?s agenda are derailing the career of the usurping State Department nominee and messing with an education bill that?s supposed to be a centerpiece of the president-elect?s first 100 days.

The series is much more a Sun Tzu procedural and Machiavellian soap opera than a Washington satire or political thriller. (Underwood?s party exists in opposition to Republicans, but I do not believe that the two episodes previewed for critics call him a Democrat. He might be a ?Whig? or something, this being the kind of show where the big D.C. paper is the Washington Herald.) Its views are post-idealistic, profitably so. We?re all familiar with shows and movies where enterprising young journalists file pointless string while pining to write five-part New Yorker stories about wheat. House of Cards, not unrefreshingly, instead gives us an apple-cheeked newspaper reporter (Kate Mara) who would kill for the chance to write sensationalistic blog posts. High-level sources on the congressman?s staff say that she and Underwood hit it off great.

Many fine throwaway lines presume our fluency in doublespeak. When he still thinks he has a shot at the State job, Underwood says, ?I?d like to coin the phrase ?trickle-down diplomacy.? ? Soon after, we see his wife correcting a misimpression about how she plans to spin a new initiative: ?No, no, I?m gonna say that we?re ?expanding our mission.? ? Wright?s character runs an outfit called the Clean Water Initiative, which will be falling on hard times now that Frank is no longer a highly desirable person up to whom to suck. Considering the nature of the series, I was surprised to learn that the Clean Water Initiative is actually a pollution-fighting nonprofit and not a lobbying organization representing the interests of Giardia cells.

Too jaded to lament the backroom maneuvering of politicians, the creators of House of Cards instead take that state of affairs as a given, tart it up, and fashion a wry piece of escapism?a backstabbing procedural delivered in a sophisticated style. And who are the creators of House of Cards? Well, the credits say that Beau Willimon adapted the show from a British series inspired by a British novel, but the substance of the show indicates that it is based on an original screenplay by Cesare Borgia, with an uncredited Dick Cheney contributing a punch-up. And maybe they brought in Joe Eszterhas to work on the part about Underwood blackmailing a coke-addled, whoremongering, drinking-and-driving colleague into doing his dirty work.

This is a very fine part for Spacey, with the dialogue playing simultaneously to his greatest strengths and his most intriguing weaknesses. Underwood hails from South Carolina, and though Spacey?s accent is inexact, the tangy fact of its existence leads to some memorable line readings. Channeling his occasional tendency toward orotund excess into stretching vowels and barbecuing syllables, he builds seductive rhythms and gets us rooting for an amoral hero. My favorite of his speeches comes early in the second episode and defines the character almost as nicely as it defines a crucial difference: ?Money is the McMansion in Sarasota that starts falling apart after 10 years. Power is the old stone house that stands for centuries. I cannot respect someone who doesn?t see the difference.?

Spacey?s glazed-ham delivery of the line is so chewy that I began to imagine cults of young Capitol Hill wannabes adopting Underwood as a philosophical idol. It?s well within the realm of possibility. Think about the all money-hungry kids who worship Gordon Gekko, the man who advised Bud Fox that it?s trench warfare out there on Wall Street: ?You win a few, you lose a few, but you keep on fighting. And if you need a friend, get a dog.?

Source: http://feeds.slate.com/click.phdo?i=2b52502ad47ded18afe777b7bcfff52e

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